Design, Synthesis, and Biological Activity of Novel Ornithine Decarboxylase (ODC) Inhibitors

We here describe the design, synthesis, and biological activity of novel ornithine decarboxylase (ODC) inhibitors that show significantly higher potency <i>in vitro</i> than α-difluoromethylornithine (DFMO), a U.S. Food and Drug Administration (FDA) approved drug. We report two X-ray str...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Chad R. Schultz (4686190) (author)
مؤلفون آخرون:	Bilal Aleiwi (7495334) (author), X. Edward Zhou (8566920) (author), Kelly Suino-Powell (376647) (author), Karsten Melcher (301766) (author), Nuno M. S. Almeida (14323012) (author), Angela K. Wilson (1269099) (author), Edmund L. Ellsworth (2521243) (author), André S. Bachmann (2050090) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Pharmacology Biotechnology Immunology Cancer Hematology Chemical Sciences not elsewhere classified Information Systems not elsewhere classified novel ornithine decarboxylase clinically validated target human odc enzyme report two x ray structures reveal potent odc inhibitors new odc inhibitors ray structures odc inhibitor odc complexed endogenous odc vitro </ superior activity several indications pyridoxal phosphate polyamine levels physical properties molecular dynamics experimental models enzymatic testing drug administration covalent adducts computational docking clinical use cellular activity biological activity approved drug active site
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Design, Synthesis, and Biological Activity of Novel Ornithine Decarboxylase (ODC) Inhibitors

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