Protocol of a target trial emulation to estimate the effect of Paxlovid treatment during acute COVID-19 on cumulative PASC incidence.

Protocol of a target trial emulation to estimate the effect of Paxlovid treatment during acute COVID-19 on cumulative PASC incidence.

<p>Protocol of a target trial emulation to estimate the effect of Paxlovid treatment during acute COVID-19 on cumulative PASC incidence.</p>

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Bibliographic Details
Main Author:	Alexander Preiss (11725774) (author)
Other Authors:	Abhishek Bhatia (15224489) (author), Leyna V. Aragon (22250805) (author), John M. Baratta (15224486) (author), Monika Baskaran (22250808) (author), Frank Blancero (22250811) (author), Michael Daniel Brannock (22272395) (author), Robert F. Chew (4397755) (author), Iván Díaz (5662771) (author), Megan Fitzgerald (14875194) (author), Elizabeth P. Kelly (20577511) (author), Andrea G. Zhou (22250814) (author), Thomas W. Carton (16979380) (author), Christopher G. Chute (8754639) (author), Melissa Haendel (14045) (author), Richard Moffitt (12043127) (author), Emily Pfaff (8563671) (author)
Published:	2025
Subjects:	Medicine Neuroscience Biotechnology Immunology Cancer Mental Health Infectious Diseases Virology Computational Biology xlink "> preventing xlink "> although stratified analyses suggest public health priority pooled individual record medical history covariates charlson comorbidity index causal interpretation relies study &# 8212 paxlovid held promise subsequent pasc incidence overall pasc incidence estimated paxlovid ’ small protective effect nationally sampled cohort absolute risk difference 19 vaccination status paxlovid treatment due patients prescribed paxlovid six sequential trials contemporary study period trial start day ard − 1 incident respiratory symptoms long covid onset study ’ pasc incidence paxlovid treatment sequential trials sequential trial see paxlovid paxlovid may respiratory symptoms pasc preventive long covid treatment group risk patients 738 patients − 0 wide range significant effect severe covid secondary outcomes remained untreated relative risk primary outcome main limitation level data incident cognitive definitive solution
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