Characterization of CD3<sup>+</sup> T-cell spatial distribution in the CRC tumor microenvironment using TIPC.

<p>Using the optimal subregion size of 35 µm and input cluster number of 9 (which was jointly determined using (a) the consensus cumulative distribution function (CDF) delta plot (k ≥ 4) and (b) tracking plot (k = 9), see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/jo...

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المؤلف الرئيسي:	Mai Chan Lau (3135303) (author)
مؤلفون آخرون:	Jennifer Borowsky (4682548) (author), Juha P. Väyrynen (10059379) (author), Koichiro Haruki (12271688) (author), Melissa Zhao (5964767) (author), Andressa Dias Costa (15158778) (author), Simeng Gu (6438257) (author), Annacarolina da Silva (14993619) (author), Tomotaka Ugai (12271682) (author), Kota Arima (2621425) (author), Minh N. Nguyen (15090738) (author), Yasutoshi Takashima (6887651) (author), Joe Yeong (3760072) (author), David Tai (4672708) (author), Tsuyoshi Hamada (401047) (author), Jochen K. Lennerz (15022851) (author), Charles S. Fuchs (14900337) (author), Catherine J. Wu (354317) (author), Jeffrey A. Meyerhardt (12271697) (author), Shuji Ogino (30267) (author), Jonathan A. Nowak (12271700) (author)
منشور في:	2025
الموضوعات:	Cell Biology Genetics Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Plant Biology Virology Mathematical Sciences not elsewhere classified Information Systems not elsewhere classified supervised machine learning sup >+</ sup similarly low densities high colorectal cancers hepatocellular carcinoma cases certain molecular pathologic cell densities among rich &# 8217 four hot subtypes achieved using multiplexed various cellular constituents rectal adenocarcinoma data immune cell infiltrates immune cell counts reference cold subtype comprising two cold upgrade tumor subtyping unique spatial patterns namely &# 8216 lymphocyte distribution patterns two tumor subtypes identified using morphology tumor immune microenvironment &# 8216 immune partitioning cell density tumor microenvironment results using organizational patterns tipc subtypes spatial relationships lymphocyte identification existing data cellular organization tumor epithelial tumor cells termed tumor identifying tumor type analyses stromal component stromal areas strictly correlate prognostic significance prognostic features prognostic benefits precision oncology nearest neighbor lymphocytes linked fully capture computational algorithm cd8 +— analysis showed also applied 570 ).
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Characterization of CD3<sup>+</sup> T-cell spatial distribution in the CRC tumor microenvironment using TIPC.

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