Principle component analysis of the expression of mRNA in U937 cells in the presence / absence of fentanyl.

Principle component analysis of the expression of mRNA in U937 cells in the presence / absence of fentanyl.

<p><b>(A)</b> Antiviral, <b>(B)</b> cell death, <b>(C)</b> chemokine, <b>(D)</b> interferon, and <b>(E)</b> NFκB signaling genes that are significantly differentially expressed (red circle = no fentanyl and cyan circle = fentanyl trea...

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Bibliographic Details
Main Author:	Janani Madhuravasal Krishnan (19736002) (author)
Other Authors:	Ling Kong (419944) (author), Heidi L. Meeds (10097746) (author), Krishna M. Roskin (13023719) (author), Mario Medvedovic (1779) (author), Kenneth E. Sherman (7573052) (author), Jason T. Blackard (7573046) (author)
Published:	2025
Subjects:	Medicine Genetics Molecular Biology Neuroscience Immunology Cancer Mental Health Infectious Diseases Virology time pcr targeting suppress immunologic responses optimized treatment strategies ccr5 chemokine receptors better understand opioid opioid use disorder accelerated disease progression hiv p24 antigen enhance viral replication ccr5 protein levels u937 cell line proviral dna levels chemokine receptor expression promote hiv replication hiv proviral dna synthetic opioid fentanyl macrophages </ p proviral dna hiv replication hiv protein expression levels viral hepatitis u937 cells synthetic opioids severe disease pol </ illicit use cell lysates hiv pathogenesis xlink "> virus interactions varying concentrations significant decrease several micrornas several drugs primary mdms investigated thoroughly infected cells higher risk fentanyl compared drug exposure develop new derived macrophages data demonstrate culture supernatants contract infections cells infected
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