Intracellular Binding of Novel Fluorinated Compounds to Carbonic Anhydrase Isoforms Explored by In-Cell <sup>19</sup>F NMR

One of the most important challenges of drug development is identifying whether a candidate molecule can efficiently reach and engage intracellular targets. Cell-based assays are usually employed to address this issue; nevertheless, many compounds that appear promising in vitro fail in cellular or i...

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Váldodahkki:	Azzurra Costantino (14335413) (author)
Eará dahkkit:	Letizia Barbieri (208263) (author), Simone Giovannuzzi (15345429) (author), Alessio Nocentini (3355211) (author), Claudiu T. Supuran (24658) (author), Mindaugas Raitelaitis (22501662) (author), Pär Nordlund (1286130) (author), Lucia Banci (120160) (author), Enrico Luchinat (208276) (author)
Almmustuhtton:	2025
Fáttát:	Biochemistry Genetics Pharmacology Biotechnology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified vivo contexts due various cytosolic isoforms qualitative affinity ranking future competitive screenings low intracellular activity engage intracellular targets novel fluorinated compounds nonfluorinated drug candidates fluorinated compounds characterized assessed target engagement living human cells f nmr one 19 </ sup f nmr target effects many compounds compounds toward intracellular binding vitro fail usually employed selective inhibitors promising scaffolds membrane permeability may serve important challenges identifying whether efficiently reach drug development chemical probes carbonic anhydrase candidate molecule appear promising
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Intracellular Binding of Novel Fluorinated Compounds to Carbonic Anhydrase Isoforms Explored by In-Cell <sup>19</sup>F NMR

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