Program replication depends on the number of cells.
<p>Same as <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1013387#pcbi.1013387.g007" target="_blank">Fig 7C</a> and D—instead of taking downsamples of unperturbed cells from Replogle et al., 2022, we downsample the entire experiment t...
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2025
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| Summary: | <p>Same as <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1013387#pcbi.1013387.g007" target="_blank">Fig 7C</a> and D—instead of taking downsamples of unperturbed cells from Replogle et al., 2022, we downsample the entire experiment to various study sizes. Here, the “entire experiment” is the normalized expression measurements of 5,247 genes in 932,593 control and intervened-upon cells which received one of the 5,247 perturbations in our analysis subset (<b>Methods</b>). We compare singular vectors (left) and programs (right) from the resulting downsamples of the entire experiment, as well as the subsets from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1013387#pcbi.1013387.g007" target="_blank">Fig 7C</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1013387#pcbi.1013387.g007" target="_blank">D</a>. We note that the 75,328 control cells replicate the programs from the entire dataset comparably to 30,000 cells from the entire experiment.</p> <p>(TIFF)</p> |
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