Chain-length specific phospholipid and diacylglycerol abnormalities in peroxisomal mutant larvae.

Chain-length specific phospholipid and diacylglycerol abnormalities in peroxisomal mutant larvae.

<p>A. Total levels in mol% of phosphatidylethanolamine (PE) in <i>pex2</i> and <i>pex16</i> larvae shows a mild but statistically significant increase in total PE in <i>pex2</i> mutant larvae compared to pex2 rescue (ratio <i>pex2/pex2 rescue</i>...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Michael F. Wangler (21526595) (author)
مؤلفون آخرون:	Yu-Hsin Chao (4166926) (author), Mary Roth (4851805) (author), Ruth Welti (120203) (author), James A. McNew (14259535) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Cell Biology Genetics Cancer Chemical Sciences not elsewhere classified substrate channeling effects secondary biochemical alterations nervous system functions long chain lysophosphatidylcholines long chain lengths intermediate fatty acids intermediate chain lengths ceramide lipid classes autosomal recessive defects allowing newborn screening 22 carbon lengths systemic disease presenting de novo </ long acyl chains identify phospholipid abnormalities div >< p subsequent imbalance due observations suggest pbd acyl chains peroxisomal disease likely due results suggest data suggest pex2 </ pex16 </ pex1 </ drosophila </ widespread impact reduced levels peroxisome formation normal levels multiple phospholipid lipidomic studies lands cycle kennedy pathway increased suggesting fundamental role fly model diseases characterized dag species dag ), brain characterized also observed
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