Design, Synthesis, and Evaluation of Antifibrotic Activity of Nonsteroidal VDR Agonists Featuring 1,6-Naphthol as a CD-Ring Surrogate

Design, Synthesis, and Evaluation of Antifibrotic Activity of Nonsteroidal VDR Agonists Featuring 1,6-Naphthol as a CD-Ring Surrogate

Chronic liver diseases activate hepatic stellate cells (HSCs), driving excessive deposition of extracellular matrix (ECM) and leading to liver fibrosis. Despite being a crucial precursor to cirrhosis, effective targeted antifibrotic therapies are lacking. Activation of the vitamin D receptor (VDR) h...

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Bibliographic Details
Main Author: Yi Gao (112914) (author)
Other Authors: Yue Wu (1262184) (author), Chun Guan (1304166) (author), Nuo Cheng (9472327) (author), Yu Tong (311947) (author), Cong Wang (107450) (author), Can Zhang (56016) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Medicine
Cell Biology
Genetics
Pharmacology
Cancer
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
yet prolonged use
conjugated triene moiety
potent antifibrotic activity
nonsteroidal vdr modulators
b20 </ b
b15 </ b
antifibrotic activity
vitro </
side chains
promising therapeutics
murine model
liver fibrosis
findings highlight
extracellular matrix
crucial precursor
carbon tetrachloride
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