Design, Synthesis, and Evaluation of Antifibrotic Activity of Nonsteroidal VDR Agonists Featuring 1,6-Naphthol as a CD-Ring Surrogate

Chronic liver diseases activate hepatic stellate cells (HSCs), driving excessive deposition of extracellular matrix (ECM) and leading to liver fibrosis. Despite being a crucial precursor to cirrhosis, effective targeted antifibrotic therapies are lacking. Activation of the vitamin D receptor (VDR) h...

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Bibliographic Details
Main Author:	Yi Gao (112914) (author)
Other Authors:	Yue Wu (1262184) (author), Chun Guan (1304166) (author), Nuo Cheng (9472327) (author), Yu Tong (311947) (author), Cong Wang (107450) (author), Can Zhang (56016) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Medicine Cell Biology Genetics Pharmacology Cancer Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified yet prolonged use conjugated triene moiety potent antifibrotic activity nonsteroidal vdr modulators b20 </ b b15 </ b antifibrotic activity vitro </ side chains promising therapeutics murine model liver fibrosis findings highlight extracellular matrix crucial precursor carbon tetrachloride
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Design, Synthesis, and Evaluation of Antifibrotic Activity of Nonsteroidal VDR Agonists Featuring 1,6-Naphthol as a CD-Ring Surrogate

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