The conserved DDVF-interacting region contributes to an RSK-mediated negative feedback of the ERK-MAPK pathway in HeLa cells.

<p><b>A.</b> Several proteins from the RAS-MAPK pathway bear a DDVF-like motif (purple) [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1013016#ppat.1013016.ref031" target="_blank">31</a>]. In the case of SPRED2, FGFR1 an...

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Bibliographic Details
Main Author:	Martin Veinstein (20958024) (author)
Other Authors:	Vincent Stroobant (2073988) (author), Fanny Wavreil (14248238) (author), Thomas Michiels (76922) (author), Frédéric Sorgeloos (427428) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Cancer Inorganic Chemistry Infectious Diseases Plant Biology Virology Computational Biology Biological Sciences not elsewhere classified varicella zoster virus two candidates identified murine encephalomyelitis virus immunoprecipitation experiments show hijack cellular kinases associated herpes virus erk mapk pathway rsk sequences suggested short linear motif div >< p novel rsk partners docking site suggests ddvf &# 8221 rsk might interact cnksr2 act upstream pathogens ’ proteins rsk partners theiler ’ alphafold docking &# 8220 several partners erk activation rsk lacking rsk binding motif used like motif dsvf motif yersinia </ would interact tmev infection tmev ), thereby altering taken together similar interface remarkable conservation recently documented proteins related proteins carrying physiological role one used negative feed mutated form kaposi sarcoma human proteome endogenous ddvf dependent manner data suggest containing proteins cells expressing bacterial proteins
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The conserved DDVF-interacting region contributes to an RSK-mediated negative feedback of the ERK-MAPK pathway in HeLa cells.

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