Secreted ISG15 modulates the immune response during Ct FGT infection.

Secreted ISG15 modulates the immune response during Ct FGT infection.

<p>Schematic representation of the immunomodulatory functions of ISG15 in the FGT during Ct infection. After Ct infection, genital epithelial cells release ISG15. ISG15, in synergy with IL-12 and IL-18, potentiates the production of IFN-γ by NK cells, contributing to the immune defense against...

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Bibliographic Details
Main Author: Yongxia Guo (8564418) (author)
Other Authors: Sigrun V. Stulz (21681424) (author), David Komla Kessie (11870621) (author), Nadine Vollmuth (15301711) (author), Tommaso Torcellan (21681427) (author), Klaus-Peter Knobeloch (50254) (author), Georg Gasteiger (2314) (author), Thomas Rudel (127432) (author)
Published: 2025
Subjects:
Microbiology
Cell Biology
Genetics
Ecology
Immunology
Infectious Diseases
uterine horn pathology
immunoregulatory cytokine essential
div >< p
critical dual function
18ra ), demonstrating
controlling bacterial load
murine infection model
controlling chlamydial infection
human primary cells
chlamydia trachomatis </
18 receptor alpha
nk cells lacking
secreted isg15 induced
chlamydia </
bacterial infections
nk cells
unconjugated form
ubiquitin family
stimulatory effect
stimulated gene
process known
polarizing signal
natural killer
intracellular pathogens
inflammatory responses
infected isg15
host resistance
host proteins
exist either
covalently attached
completely abolished
cellular immunity
10 levels
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