Supporting articles for the proposed ccRCC-causing KGs and suggested drug molecules.

Supporting articles for the proposed ccRCC-causing KGs and suggested drug molecules.

<p>(A) Supporting articles with the KGs and (B) supporting articles with the suggested drugs, where the red ellipse indicates FDA-approved drugs and the experimental drugs are indicated by the green ellipse.</p>

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Alvira Ajadee (19762306) (author)
مؤلفون آخرون: Sabkat Mahmud (19762309) (author), Md. Bayazid Hossain (19762312) (author), Reaz Ahmmed (19762315) (author), Md. Ahad Ali (16909085) (author), Md. Selim Reza (12368716) (author), Saroje Kumar Sarker (19762318) (author), Md. Nurul Haque Mollah (8946176) (author)
منشور في: 2024
الموضوعات:
Cell Biology
Genetics
Molecular Biology
Pharmacology
Developmental Biology
Cancer
Hematology
Biological Sciences not elsewhere classified
yet completely known
mediated receptor proteins
almost 2 years
understand molecular mechanisms
targeted different variants
significant prognostic power
literature review also
control samples based
causing key genes
causing molecular functions
though drug therapies
tcga database showed
gene regulatory network
effective treatment strategy
div >< p
obtained 54 scdegs
effective treatment
molecular docking
significant association
microarray gene
independent tcga
gtex database
different subtypes
causing top
54 scdegs
network analysis
kgs based
causing kgs
useful inputs
used protein
umod </
transcriptional regulators
therapeutic drugs
slc12a3 </
slc12a1 </
serpina5 </
reduced set
protein interaction
prevalent subtype
positively correlated
plg </
outputs might
negatively correlated
may lead
kidney cancer
independent receptors
genetic alterations
expression datasets
eno2 </
dovitinib .)
crucial transcriptional
cellular components
biological processes
best choice
also supported
aldob </
aldh6a1 </
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