Supplementary file 2_Lycii radicis cortex alleviates fibrosis in hiPSC-derived multilineage hepatic organoids via the cAMP-PKA pathway.docx

Supplementary file 2_Lycii radicis cortex alleviates fibrosis in hiPSC-derived multilineage hepatic organoids via the cAMP-PKA pathway.docx

Background<p>Liver fibrosis, driven by excessive extracellular matrix (ECM) deposition and activation of hepatic stellate cells (HSCs), still lacks effective therapies, partly due to the absence of human-relevant models. Lycii Radicis Cortex (LRC), a traditional Chinese medicine, exhibits repo...

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Hlavní autor: Junming Xu (1716112) (author)
Další autoři: Xiaopu Sang (8502954) (author), Yongfei He (21372968) (author), Jie Ke (2005411) (author), Jiasen Xu (729951) (author), Tanbin Liu (4849807) (author), Jicai Wang (21372977) (author), Hang Zhai (1540051) (author), Xiaoni Chen (8502957) (author), Xianjie Shi (3567419) (author), Fenfang Wu (3157299) (author)
Vydáno: 2025
Témata:
Pharmacology
natural products
IPSCs (induced pluripotent stem cells)
organoid
liver fibrosis
lycii radicis cortex
cAMP–PKA–CREB pathway
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