Effect of i.v. injection of juvenile and adult B. lanceolatus venoms on classical clotting tests.

20 μg venom from juvenile or adult specimens, dissolved in 100 μL PBS, were injected i.v. in mice. Controls received 100 μl PBS. One hour after injection mice were bled under isoflurane anesthesia and blood was collected, added to citrate anticoagulant, and centrifuged for plasma collection...

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Bibliographic Details
Main Author:	Alexandra Rucavado (32147) (author)
Other Authors:	Erika Camacho (19787243) (author), Teresa Escalante (337914) (author), Bruno Lomonte (181809) (author), Julián Fernández (5660767) (author), Daniela Solano (11388137) (author), Isabel Quirós-Gutiérrez (19787246) (author), Gabriel Ramírez-Vargas (19787249) (author), Karol Vargas (19787252) (author), Ivette Argüello (19787255) (author), Alejandro Navarro (8364654) (author), Carlos Abarca (19787258) (author), Álvaro Segura (11388131) (author), Jonathan Florentin (2817559) (author), Hatem Kallel (4630924) (author), Dabor Resiere (12902657) (author), Remi Neviere (146063) (author), José María Gutiérrez (8648055) (author)
Published:	2024
Subjects:	Biochemistry Evolutionary Biology Ecology Developmental Biology Mental Health Hematology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified viperid species endemic rotational thromboelastometry parameters metalloproteinase inhibitor batimastat lesser antillean island consumption coagulopathy characteristic classical clotting tests citrated mouse plasma murine experimental model experimental model reproduces thrombotic effect induced juvenile specimens induced adult venoms induced bothrops lanceolatus </ adult venom proteomes experimental model mouse model lanceolatus </ bothrops </ adult specimens venom proteomes thrombotic events juvenile specimens adult venom vivo </ vitro </ venoms showed sp venoms pulmonary vasculature prothrombin time procoagulant effect procoagulant activity partial drop minor alterations marked thrombocytopenia less frequent juvenile venoms juvenile venom hemostasis alterations fibrinogen concentration either venom conspicuous thrombocytopenia changes occurred bovine fibrinogen albeit showing abundant thrombi
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Effect of i.v. injection of juvenile and adult <i>B</i>. <i>lanceolatus</i> venoms on classical clotting tests.

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