Growth characteristics of fibroblasts stably expressing AGAT and GAMT.

<p>(A) A model depicting the two sources of intracellular creatine. Creatine is either imported via CT1 or synthesized from its amino acid precursors: L-arginine; glycine; and methionine. The latter is converted into SAM via MAT2. Created with BioRender.com. (B) Growth of WT fibroblasts stably...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Chloe Wells (17231887) (author)
مؤلفون آخرون:	Jon Sorgenfrei (21273708) (author), Sadie L. Johnson (21273711) (author), Devin Albertson (21273714) (author), Jared Rutter (2128906) (author), Steven Andrew Baker (10150952) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Cell Biology Genetics Molecular Biology Mental Health target cell types natural cellular compartment highly energetic tissues critical metabolite used affected individuals suffer creatine uptake relies creatine transporter 1 healthy control fibroblasts endogenous creatine synthesis div >< p intracellular creatine concentrations intracellular synthesis transport creatine primary fibroblasts patient fibroblasts intracellular concentration slc6a8 </ selectively expressed protein product proper targeting phenotypes referred linked gene like behaviors intellectual disability hek293t cells genetic defects gene therapy gatm </ function mutations far exceeding effective therapies common set common form
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Growth characteristics of fibroblasts stably expressing AGAT and GAMT.

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