Growth characteristics of fibroblasts stably expressing AGAT and GAMT.

Growth characteristics of fibroblasts stably expressing AGAT and GAMT.

<p>(A) A model depicting the two sources of intracellular creatine. Creatine is either imported via CT1 or synthesized from its amino acid precursors: L-arginine; glycine; and methionine. The latter is converted into SAM via MAT2. Created with BioRender.com. (B) Growth of WT fibroblasts stably...

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Bibliographic Details
Main Author: Chloe Wells (17231887) (author)
Other Authors: Jon Sorgenfrei (21273708) (author), Sadie L. Johnson (21273711) (author), Devin Albertson (21273714) (author), Jared Rutter (2128906) (author), Steven Andrew Baker (10150952) (author)
Published: 2025
Subjects:
Biochemistry
Medicine
Cell Biology
Genetics
Molecular Biology
Mental Health
target cell types
natural cellular compartment
highly energetic tissues
critical metabolite used
affected individuals suffer
creatine uptake relies
creatine transporter 1
healthy control fibroblasts
endogenous creatine synthesis
div >< p
intracellular creatine concentrations
intracellular synthesis
transport creatine
primary fibroblasts
patient fibroblasts
intracellular concentration
slc6a8 </
selectively expressed
protein product
proper targeting
phenotypes referred
linked gene
like behaviors
intellectual disability
hek293t cells
genetic defects
gene therapy
gatm </
function mutations
far exceeding
effective therapies
common set
common form
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