Photoredox-Catalyzed Deoxygenative C–H Alkylation of Azauracils via Xanthate-Activated Alcohols

Photoredox-Catalyzed Deoxygenative C–H Alkylation of Azauracils via Xanthate-Activated Alcohols

A visible-light-driven method has been developed for the deoxygenative alkylation of azauracils with alcohols, utilizing xanthate salts as alkylation precursors in the presence of tricyclohexylphosphine. This approach features mild conditions, high step efficiency, and a broad substrate scope, enabl...

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Bibliographic Details
Main Author: Lili Wang (104605) (author)
Other Authors: Ling Cui (10918279) (author), Jinwei Yuan (458633) (author), Yuntao Xia (5577878) (author), Liangru Yang (2430442) (author), Yongmei Xiao (678549) (author), Dongliang Xing (17978165) (author), Lingbo Qu (699449) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Pharmacology
Biotechnology
Mental Health
Virology
utilizing xanthate salts
mediated radical pathway
mechanistic investigations suggest
involves xanthate intermediates
high step efficiency
broad substrate scope
azauracils via xanthate
thereby enhancing
reaction selectivity
driven method
deoxygenative alkylation
alkylation precursors
alkylating agents
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