Data Sheet 1_Vδ2 T-cell engagers bivalent for Vδ2-TCR binding provide anti-tumor immunity and support robust Vγ9Vδ2 T-cell expansion.docx

Data Sheet 1_Vδ2 T-cell engagers bivalent for Vδ2-TCR binding provide anti-tumor immunity and support robust Vγ9Vδ2 T-cell expansion.docx

Background<p>Vγ9Vδ2 T-cells are antitumor immune effector cells that can detect metabolic dysregulation in cancer cells through phosphoantigen-induced conformational changes in the butyrophilin (BTN) 2A1/3A1 complex. In order to clinically exploit the anticancer properties of Vγ9Vδ2 T-cells, v...

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Bibliographic Details
Main Author: Lisa A. King (17967191) (author)
Other Authors: Milon de Jong (19866936) (author), Myrthe Veth (19866939) (author), David Lutje Hulsik (19866942) (author), Parsa Yousefi (19866945) (author), Victoria Iglesias-Guimarais (15115453) (author), Pauline M. van Helden (14934032) (author), Tanja D. de Gruijl (8805821) (author), Hans J. van der Vliet (2837075) (author)
Published: 2024
Subjects:
Oncology and Carcinogenesis not elsewhere classified
Vγ9Vδ2 T-cells
bispecific T-cell engager
single domain antibody
expansion
immunotherapy
cancer
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