Activation, proliferation and effector capacities of CD56<sup>dim</sup>NKG2A<sup>+</sup>NK cells in HFRS patients by co-culture with HTNV-NP5 peptide-pulsed K562/HLA-E*0103 cells <i>ex vivo.</i>

Activation, proliferation and effector capacities of CD56<sup>dim</sup>NKG2A<sup>+</sup>NK cells in HFRS patients by co-culture with HTNV-NP5 peptide-pulsed K562/HLA-E*0103 cells <i>ex vivo.</i>

<p>Representative flow cytometric plots and changes in the frequencies of activated (HLA-DR<sup>+</sup>) (A and B), proliferated (Ki67<sup>+</sup>) (C and D) and functional (TNF-α<sup>+</sup>, perforin<sup>+</sup> and CD107a<sup>+</sup&g...

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Main Author: Manling Xue (14262008) (author)
Other Authors: Kang Tang (722079) (author), Yusi Zhang (383393) (author), Xiaoyue Xu (712736) (author), Chunmei Zhang (67508) (author), Jiajia Zuo (10258540) (author), Fenglan Wang (11652412) (author), Xiyue Zhang (4288279) (author), Xuyang Zheng (3755152) (author), Ran Zhuang (383394) (author), Yun Zhang (131894) (author), Boquan Jin (383395) (author), Ying Ma (123771) (author)
Published: 2025
Subjects:
Biochemistry
Medicine
Molecular Biology
Immunology
Cancer
Infectious Diseases
Virology
Biological Sciences not elsewhere classified
infection remain unclear
ex vivo </
div >< p
detected using ligand
cell rna sequencing
antiviral immune response
dim </ sup
enhanced cytolytic capacity
peptide affinity detection
sup >-</ sup
sup >+</ sup
derived peptides presented
α ), interferon
virus infectious diseases
receptor binding assay
inhibitory receptor cd94
derived peptide complex
nk cells showed
derived peptides
binding capacity
nk cells
cytotoxicity assay
e cells
tetramer staining
taken together
showing activation
renal syndrome
proliferation phenotypes
pathogenesis process
hemorrhagic fever
hantaan virus
functional evaluation
flow cytometry
findings demonstrate
cytotoxic mediators
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