<sup>64</sup>Cu-Labeled Stapled Peptide-Based Radiopharmaceuticals Targeting MDM2/MDMX for Pan-p53 Tumors

<sup>64</sup>Cu-Labeled Stapled Peptide-Based Radiopharmaceuticals Targeting MDM2/MDMX for Pan-p53 Tumors

The development of ideal peptide-based radiopharmaceuticals faces critical bottlenecks, primarily due to limited cellular internalization and insufficient deep tissue penetration of peptide carriers. To address this, we developed an intracellular targeting and DNA-adjacent radiotherapeutic strategy...

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Main Author: Hao Tian (568283) (author)
Other Authors: Quan Zuo (9033050) (author), Siqi Zhang (1397044) (author), Hongyi Huang (6209069) (author), Dengfu Wu (22495962) (author), Zihan Huang (1553887) (author), Xiangding Liu (22495965) (author), Lin Xie (136792) (author), Yiding Zhang (1428880) (author), Hailong Zhang (398565) (author), Yekuan Shi (22495968) (author), Suping Li (1396921) (author), Ming-Rong Zhang (136828) (author), Rui Wang (52434) (author), Kuan Hu (3349553) (author)
Published: 2025
Subjects:
Biochemistry
Medicine
Pharmacology
Biotechnology
Sociology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Physical Sciences not elsewhere classified
Information Systems not elsewhere classified
standard uptake value
slow systemic clearance
limited cellular internalization
exhibited prolonged circulation
39 ± 1
developing intracellular protein
labeled stapled peptide
administered [< sup
64 </ sup
targeting stapled peptide
intracellular targeting
[< sup
stapled peptides
peptide carriers
ideal peptide
vivo </
vitro </
targeting radiopharmaceuticals
taken together
primarily due
p53 tumors
p53 phenotypes
nearly 50
longitudinal tool
ideal vehicles
based radiopharmaceuticals
achieving efficient
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