64Cu-Labeled Stapled Peptide-Based Radiopharmaceuticals Targeting MDM2/MDMX for Pan-p53 Tumors

The development of ideal peptide-based radiopharmaceuticals faces critical bottlenecks, primarily due to limited cellular internalization and insufficient deep tissue penetration of peptide carriers. To address this, we developed an intracellular targeting and DNA-adjacent radiotherapeutic strategy...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Hao Tian (568283) (author)
مؤلفون آخرون:	Quan Zuo (9033050) (author), Siqi Zhang (1397044) (author), Hongyi Huang (6209069) (author), Dengfu Wu (22495962) (author), Zihan Huang (1553887) (author), Xiangding Liu (22495965) (author), Lin Xie (136792) (author), Yiding Zhang (1428880) (author), Hailong Zhang (398565) (author), Yekuan Shi (22495968) (author), Suping Li (1396921) (author), Ming-Rong Zhang (136828) (author), Rui Wang (52434) (author), Kuan Hu (3349553) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Pharmacology Biotechnology Sociology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified Information Systems not elsewhere classified standard uptake value slow systemic clearance limited cellular internalization exhibited prolonged circulation 39 ± 1 developing intracellular protein labeled stapled peptide administered [< sup 64 </ sup targeting stapled peptide intracellular targeting [< sup stapled peptides peptide carriers ideal peptide vivo </ vitro </ targeting radiopharmaceuticals taken together primarily due p53 tumors p53 phenotypes nearly 50 longitudinal tool ideal vehicles based radiopharmaceuticals achieving efficient
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