Design and Synthesis of Chiral Bidentate Phosphine-Free 2‑Hydroxypyridine-Oxazoline Ligands for Manganese-Catalyzed Hydrogenation

Significant progress has been made in the development of tridentate phosphine ligands for manganese-catalyzed asymmetric direct hydrogenation (ADH). However, their high cost and susceptibility to oxidation limit their further application. In contrast, bidentate phosphine-free ligands, such as bident...

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Bibliographic Details
Main Author:	Gao-Wei Wang (19745869) (author)
Other Authors:	Mu-Wang Chen (1415287) (author), Ya-Qi Wu (20314425) (author), Qing-Xian Xie (11538906) (author), Zheng Liu (28397) (author), Rong-Zhen Liao (1354074) (author), Yong-Gui Zhou (1415290) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Molecular Biology Pharmacology Biotechnology Sociology Immunology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified preliminary mechanistic studies possible catalytic pathways enhances hydrogen activation dft calculations revealed catalyzed asymmetric hydrogenation >- ligand scaffold tridentate phosphine ligands chiral bidentate phosphine bidentate phosphine asymmetric catalysis bidentate nitrogen tunable steric simple ketones shedding light remain underexplored promising potential oxidation limit oxazoline ligands n </ hydride transfer hydride species high yields high cost free ligands findings demonstrate exhibiting tautomerism electronic properties critical role chiral 2 based ligands adh ).
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Design and Synthesis of Chiral Bidentate Phosphine-Free 2‑Hydroxypyridine-Oxazoline Ligands for Manganese-Catalyzed Hydrogenation

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