Unraveling of Phosphotyrosine Signaling Complexes Associated with T Cell Exhaustion Using Multiplex Co-Fractionation/Mass Spectrometry

Unraveling of Phosphotyrosine Signaling Complexes Associated with T Cell Exhaustion Using Multiplex Co-Fractionation/Mass Spectrometry

T cell exhaustion, characterized by the upregulation of inhibitory receptors and loss of effector functions, plays a crucial role in tumor immune evasion. This study utilizes a high-throughput, reproducible, and robust integrated ion-exchange chromatography–tandem mass tag (IEC-TMT) platform, couple...

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Bibliographic Details
Main Author: Wei Liu (20030) (author)
Other Authors: Hailong Yu (329340) (author), Guoquan Yan (465897) (author), Shun Shen (1411801) (author), Mingxia Gao (1290741) (author), Xiangmin Zhang (813476) (author)
Published: 2024
Subjects:
Biophysics
Biochemistry
Medicine
Cell Biology
Genetics
Physiology
Immunology
Cancer
Hematology
Space Science
Mathematical Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
tumor immune evasion
thoroughly profile phosphotyrosine
potential therapeutic target
notably impacting lysosomal
enhancing antitumor immunity
robust integrated ion
centric quantification algorithm
protein complex changes
cell exhaustion model
robust quantification
cell exhaustion
study utilizes
molecular mechanisms
median coefficient
mass spectrometry
knockdown reversed
inhibitory receptors
endoplasmic reticulum
effector functions
crucial role
associated complexes
94 correlation
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