New model for biosynthesis of desferrioxamines B and E.

<p>a, Extracted ion chromatograms for m/z values corresponding to DFO-related metabolites in culture extracts of the knock-out mutants of SCO4048 (desJ), SCO4049 (desG), and SCO40450 (desH) compared to the parent <i>Streptomyces</i> coelicolor M145 strain. The <i>desG</i&g...

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Main Author:	Hannah E. Augustijn (10773096) (author)
Other Authors:	Zachary L. Reitz (11874511) (author), Le Zhang (88249) (author), Jeanine A. Boot (21533184) (author), Somayah S. Elsayed (9192571) (author), Gregory L. Challis (136140) (author), Marnix H. Medema (111741) (author), Gilles P. van Wezel (7838948) (author)
Published:	2025
Subjects:	Biochemistry Genetics Hematology Infectious Diseases Biological Sciences not elsewhere classified regulatory networks combined innovative strategy whereby biosynthetic gene clusters novel locus involved genome mining based based genome mining streptomyces coelicolor </ predict bgc functions functionally prioritize bgcs div >< p genome mining novel operon desh </ desg </ work shows vast majority uncovered millions strongly reduces natural products major challenge likely act key role harnessing regulation genes predicted clear product biotechnological use bioinformatic analysis bgcs specify bacteria produce
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New model for biosynthesis of desferrioxamines B and E.

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