Single-cell atlas of BMNCs shows proportional changes in key immune cell populations.

<p>(A) Study design. BMNCs were collected from 123 subjects across 4 cohorts (HVs, MGUS, SMM, and newly diagnosed MM) and were further analyzed using scRNAseq, ADT-seq and scBCRseq. (B) Expression profile of marker genes/proteins for each cell type. The ‘TotalSeqC’ extension designates the pro...

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Bibliographic Details
Main Author:	Isabelle Bergiers (481117) (author)
Other Authors:	Murat Cem Köse (22387199) (author), Sheri Skerget (824575) (author), Milan Malfait (14437769) (author), Nele Fourneau (14989871) (author), Jenna-Claire Ellis (22387202) (author), Greet Vanhoof (1638970) (author), Tina Smets (6634421) (author), Bie Verbist (758342) (author), Dries De Maeyer (823123) (author), Jeroen Van Houdt (4924933) (author), Koen Van der Borght (3537110) (author), Raluca Verona (817145) (author), Bradley Heidrich (22387205) (author), William Kurth (22387208) (author), Michel Delforge (7258289) (author), Nathalie Meuleman (58106) (author), Jan Van Droogenbroeck (11500716) (author), Philip Vlummens (221451) (author), Christoph J. Heuck (14993186) (author), Yves Beguin (264097) (author), Nizar Bahlis (8545206) (author), Tineke Casneuf (24442) (author), Jo Caers (111624) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Genetics Molecular Biology Pharmacology Immunology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified xlink "> investigation whole bone marrow surface protein profiling protocol number noprodmmy0001 novel therapeutic strategies interferon alpha response including myc signaling analyses revealed commonalities mononuclear cell samples cell rna sequencing study molecular changes molecular pathways driven eudract number 2018 classical dendritic cells downstream changes observed active disease increases molecular pathways immunophenotypic changes cell atlas molecular mechanisms disease progresses unknown significance resulting differences receptor interactions precursor stages precursor stage potential regulators potential ligand potential biomarkers population shifts plasma cells myeloma tumorigenesis multiple myeloma monoclonal gammopathy may play immune system highest potential findings demonstrate e2f targets
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Single-cell atlas of BMNCs shows proportional changes in key immune cell populations.

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