PRISMA flow diagram for included studies.

PRISMA flow diagram for included studies.

<div><p>Background</p><p>The optimal second-line systemic treatment for metastatic colorectal cancer (mCRC) is inconclusive.</p><p>Methods</p><p>We searched PubMed, Web of Science, EMBASE, and Cochrane Library for RCTs comparing second-line systemic tr...

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Bibliographic Details
Main Author:	Chengyu Sun (291981) (author)
Other Authors:	Enguo Fan (1371660) (author), Luqiao Huang (20469258) (author), Zhengguo Zhang (3284823) (author)
Published:	2024
Subjects:	Medicine Cell Biology Genetics Biotechnology Cancer patient &# 8217 metastatic colorectal cancer grade &# 8805 cumulative ranking curve 2 %); whereas 0 %, 81 therapeutic effect may 4 %, 74 rcts comparing second among multiple second 1 %, respectively subgroup analyses showed rct </ p panitumumab ranked among bayesian network meta line systemic treatments line systemic treatment 1 %, subgroup analyses network meta line treatments 4 %) 1 %) optimal second best second 44 second xlink "> type population systematic review survival outcomes significantly different significant advantage searched pubmed physiological state optimum intervention mutant populations mutant population involving 16 free survival february 3 cochrane library bevacizumab may ae ). adverse events 925 patients 7 %). 3ae ),
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