DataSheet2_Detection of Synergistic Interaction on an Additive Scale Between Two Drugs on Abnormal Elevation of Serum Alanine Aminotransferase Using Machine-Learning Algorithms.docx

DataSheet2_Detection of Synergistic Interaction on an Additive Scale Between Two Drugs on Abnormal Elevation of Serum Alanine Aminotransferase Using Machine-Learning Algorithms.docx

<p>Drug-induced liver injury (DILI) is a common adverse drug reaction, with abnormal elevation of serum alanine aminotransferase (ALT). Several clinical studies have investigated whether a combination of two drugs alters the reporting frequency of DILI using traditional statistical methods suc...

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Bibliographic Details
Main Author: Hayato Akimoto (3132798) (author)
Other Authors: Takuya Nagashima (11460427) (author), Kimino Minagawa (13006248) (author), Takashi Hayakawa (143407) (author), Yasuo Takahashi (82352) (author), Satoshi Asai (82354) (author)
Published: 2022
Subjects:
Pharmacology
Basic Pharmacology
Clinical Pharmacology and Therapeutics
Clinical Pharmacy and Pharmacy Practice
Pharmaceutical Sciences
Pharmacogenomics
Toxicology (incl. Clinical Toxicology)
Pharmacology and Pharmaceutical Sciences not elsewhere classified
machine-learning (ML) algorithms
liver function
drug induced liver injury (DILI)
alanine aminotransferase
drug interaction
relative excess risk due to interaction (RERI)
synergistic effect
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