TBKBP1 overexpression in restimulated CD8+ T cells results in increased TBK1 phosphorylation.

PBMCs obtained from CMV-seronegative healthy donors were stimulated with plate-bound anti-human CD3 and anti-human CD28 for 48 hours and subsequently retrovirally transduced with TBKBP1-expressing vectors or empty vector (EV) controls. Successfully transduced CD8+mChe...

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Main Author:	Zheng Yu (484983) (author)
Other Authors:	Varun Sasidharan-Nair (19746817) (author), Thalea Buchta (19746820) (author), Agnes Bonifacius (9127764) (author), Fawad Khan (12280549) (author), Beate Pietzsch (520754) (author), Hosein Ahmadi (8837264) (author), Michael Beckstette (683885) (author), Jana Niemz (19654480) (author), Philipp Hilgendorf (19746823) (author), Philip Mausberg (12397006) (author), Andreas Keller (29147) (author), Christine Falk (109913) (author), Dirk H. Busch (6893231) (author), Kilian Schober (12635697) (author), Luka Cicin-Sain (3385982) (author), Fabian Müller (30745) (author), Melanie M. Brinkmann (9500135) (author), Britta Eiz-Vesper (109926) (author), Stefan Floess (24038) (author), Jochen Huehn (8746) (author)
Published:	2024
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Immunology Developmental Biology Cancer Hematology Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified sup >+</ sup stable upon long genome bisulfite sequencing dna methylation pattern div >< p binding kinase 1 tbkbp1 overexpression resulted binding protein 1 although adoptive transfer virus neutralization capacity intracellular virus sensing terminal effector cd8 top demethylated dmrs tbkbp1 modulates virus specific human cd8 tbkbp1 </ since tbkbp1 protein level improve adoptive virus infection specific cd8 memory cd8 vitro </ therapeutic target significantly improved potent amplifier performed whole mediate pro largely unknown inflammatory responses immunocompromised individuals data demonstrate cytotoxic activity clinically applied cell subsets cell responses cell differentiation alternative splicing >, coding
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TBKBP1 overexpression in restimulated CD8<sup>+</sup> T cells results in increased TBK1 phosphorylation.

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