Cryo-EM analysis of the CD163/Hp(1–1)Hb complex.

Cryo-EM analysis of the CD163/Hp(1–1)Hb complex.

<p><b>(A)</b> Flow chart of data processing. Details can be found in the Image processing section. <b>(B)</b> Representative cryo-EM micrograph. <b>(C)</b> Representative 2D class averages. <b>(D)</b> Local resolution estimation and orientation d...

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Wedi'i Gadw mewn:

Manylion Llyfryddiaeth
Prif Awdur:	Ching-Shin Huang (21703202) (author)
Awduron Eraill:	Hui Wang (30400) (author), Joshua B. R. White (14254170) (author), Oksana Degtjarik (2810629) (author), Cindy Huynh (2697772) (author), Kristoffer Brannstrom (21703205) (author), Mark T. Horn (21703208) (author), Stephen P. Muench (236881) (author), William S. Somers (2659714) (author), Javier Chaparro-Riggers (15013755) (author), Laura Lin (2272402) (author), Lidia Mosyak (1635880) (author)
Cyhoeddwyd:	2025
Pynciau:	Biophysics Biochemistry Cell Biology Molecular Biology Pharmacology Immunology Cancer Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified renal tissues due haptoglobin &# 8211 circulating haptoglobin acts bound receptor assemblies electron microscopy structures composite binding site 1 binding stoichiometry cd163 scavenger receptor cd163 remains unclear molecular mechanism underlying hemoglobin clearance mechanism ligand binding site molecular mechanism structures reveal human cd163 cd163 functions unliganded state study elucidates structural elucidation primary defense oxidative nature one protomer mostly well free hemoglobin damage vascular autoinhibitory configuration also form
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