Design, Synthesis and Preclinical Evaluation of a Brain-Permeable PET Tracer for P2Y12 Receptor Imaging in the Brain

Microglia, the innate immune cells of the central nervous system (CNS), act as first responders to brain injury. Their ability to switch between different neuroprotective and neurotoxic phenotypes, plays a central role in maintaining brain homeostasis. Recently, the P2Y12 receptor (P2Y12R) has been...

詳細記述

保存先:

書誌詳細
第一著者:	Emanuel Joseph (9519842) (author)
その他の著者:	Lea H. Kunze (13965969) (author), Rebecca Schaefer (11358882) (author), Giovanna Palumbo (7880306) (author), Benjamin Kugelmann (21789776) (author), Stephan Wagner (1802947) (author), Sven Lammich (21789779) (author), Regina Feederle (166063) (author), Michael Willem (10959531) (author), Rudolf A. Werner (12034430) (author), Matthias Brendel (694662) (author), Simon Lindner (1820299) (author)
出版事項:	2025
主題:	Biochemistry Medicine Cell Biology Neuroscience Pharmacology Immunology Mental Health valuable diagnostic tool promising molecular biomarker nicotinate [< sup innate immune cells f ]< b exhibited nanomolar affinity cns ), act 18 </ sup 12 </ b central nervous system pet data revealed ex vivo </ sufficient brain retention maintaining brain homeostasis permeable pet tracer p2y12r expression levels p2y12 receptor imaging vivo </ p2y12 receptor tracer uptake expression level central role target receptor brain injury brain microglia strong correlation reduced uptake preclinical evaluation neurotoxic phenotypes first responders different neuroprotective
タグ:	タグ追加タグなし, このレコードへの初めてのタグを付けませんか!

Design, Synthesis and Preclinical Evaluation of a Brain-Permeable PET Tracer for P2Y12 Receptor Imaging in the Brain

類似資料