Model of multiple myeloma treatment with Dara (control, <i>u</i>), including an immune response (purple arrows) and drug resistance mechanisms via loss of CD38 expression.

Eitemau Tebyg

• Model parameters with descriptions and default values. The right-hand side column gives the parameter values for a simplified model (Null-N).
  gan: James G. Lefevre (11303976)
  Cyhoeddwyd: (2025)
• Optimal control solutions for the linear cost function with zero or default off-target drug effect (), no immune response (), reduced expression switching (, default ), and induced loss of expression set to either zero or the default value ().
  gan: James G. Lefevre (11303976)
  Cyhoeddwyd: (2025)
• Selected optimal control solutions for the linear cost function where either expression switching (top row, ) or drug induced loss of expression (bottom row, ) is removed from the model.
  gan: James G. Lefevre (11303976)
  Cyhoeddwyd: (2025)
• Optimal control solutions for the linear cost function with increased off-target drug effect (; default 0.1), reduced expression switching (, default ), reduced or default immune strength (, default 0.15), and default or increased drug induced loss of expression (, default 0.2).
  gan: James G. Lefevre (11303976)
  Cyhoeddwyd: (2025)
• Optimal control solutions for different off-target drug effect magnitudes (); default value .
  gan: James G. Lefevre (11303976)
  Cyhoeddwyd: (2025)