Depletion of SAS4 in spermatocytes leads to male infertility.

Depletion of SAS4 in spermatocytes leads to male infertility.

<p><b>A.</b> Diagram of the <i>Sas4</i> cKO allele before and after Cre-mediated recombination. The <i>Sas4</i> flox allele harbors two loxP sites (blue triangle) flanking exon 5 (grey box). Excision of exon 5 by Cre recombinase results in the <i>Sas4&...

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Bibliographic Details
Main Author:	Marnie W. Skinner (14660004) (author)
Other Authors:	Paula B. Nhan (18471984) (author), Carter J. Simington (17145830) (author), Philip W. Jordan (14660022) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Developmental Biology Cancer Physical Sciences not elsewhere classified understanding certain conditions pericentriolar matrix proteins murine conditional knockout disrupted acrosome morphology constricted perinuclear rings male infertility associated div >< p round spermatid formation require centriole duplication mice </ p male germ cells centriole duplication male fertility sas4 </ centriole biogenesis traditionally viewed still capable sperm maturation organizing centers meiotic divisions inherited fewer infertile due functional spermatozoa form flagella findings demonstrate critical component chromosome segregation centrosomal mtoc
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