Correlation between GTEx and GWAS Z-scores of eQTLs from HLA-DQB1, HLA-DQA2 and HLA-DRB6.

Z-scores were calculated from T2D GWAS and GTEx (version 8) summary statistics for all the eQTLs for the three genes. Pearson correlation coefficient was calculated, and scatter plots were generated for eQTL data from five different tissues. Most of the TG lowering variants increases the ex...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Margaret Sunitha Selvaraj (13994016) (author)
مؤلفون آخرون:	Kaavya Paruchuri (13994019) (author), Sara Haidermota (13994022) (author), Rachel Bernardo (13994025) (author), Stephen S. Rich (7634141) (author), Gina M. Peloso (12036929) (author), Pradeep Natarajan (819434) (author)
منشور في:	2022
الموضوعات:	Genetics Molecular Biology Biotechnology Marine Biology Cancer Infectious Diseases Virology Mathematical Sciences not elsewhere classified minor allele count located 2kb upstream cochran &# 8217 wide significant heterogeneity wide association study intergenic variant near discover loci associated 120 genotyped participants type 1 diabetes lead variant rs9274619 finding among 25 conducted association analyses allele frequency 0 951 t2d cases 4 %; p 32 exhibited genome type 2 diabetes significantly associated variants 2 </ sup lead variant wide discovery strongly associated significantly associates genetic variants 137 participants dqa2 </ xlink "> uk biobank t2d status t2d samples t2d ). least 20 immune overlap effect estimates effect differences dependent triglycerides decreased triglycerides concomitant diagnosis cohort based among 21 176 t2d
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Correlation between GTEx and GWAS Z-scores of eQTLs from <i>HLA-DQB1</i>, <i>HLA-DQA2</i> and <i>HLA-DRB6</i>.

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