IR-induced mutation clusters in DR, BER and RecQ helicase mutants.

<p>Sizes of IR-induced mutation clusters shown in bp spanned by the mutation cluster (top panel) and as the number of mutations per cluster (bottom panel). Grey or black dots indicate bp spanned or mutations by cluster, respectively, observed in individual lines of the indicated genotypes. Bla...

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Bibliographic Details
Main Author:	Bettina Meier (274833) (author)
Other Authors:	Nadezda V. Volkova (10711477) (author), Bin Wang (30851) (author), Víctor González-Huici (10711483) (author), Simone Bertolini (10711480) (author), Peter J. Campbell (10711489) (author), Moritz Gerstung (198409) (author), Anton Gartner (208255) (author)
Published:	2021
Subjects:	Biophysics Biochemistry Medicine Microbiology Genetics Molecular Biology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified translesion polymerase mutants dna repair pathways div >< p damage response defective bulky dna adducts base changes decreased 43 dna repair 11 genotoxic agents significantly higher frequency dna damage induced increased dinucleotide substitutions frequency increased 2 wide mutagenic consequences mutagenic consequences significantly altered induced lesions widely used structural variants small deletions relative contribution recent high nucleotides equally mutations occurred model system major concern level overview ionizing radiation germ cells fold concurrently exposing wild environmental exposure emitting γ elegans </ cancer therapy c </ better understanding act cooperatively
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IR-induced mutation clusters in DR, BER and RecQ helicase mutants.

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