Figure 4 from Screening FDA-Approved Oncology Drugs with Three-Dimensional Spheroids Identifies Romidepsin as a Therapeutic Candidate for Osteosarcoma

Figure 4 from Screening FDA-Approved Oncology Drugs with Three-Dimensional Spheroids Identifies Romidepsin as a Therapeutic Candidate for Osteosarcoma

<p>Romidepsin has the largest overall therapeutic index of all 13 hits from the initial screen. Data represent dose–response experiments for top 13 hits from initial screen. Ratios of TD<sub>50</sub>/sarcosphere (Sarco) ED<sub>50</sub> reflect therapeutic indices with N...

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Autor Principal: Emily E. Seiden (22436851) (author)
Outros autores: Spencer M. Richardson (22436854) (author), Leah A. Everitt (22436857) (author), Gabrielle J. Knafler (22436860) (author), Alyssa L. Walker (22436863) (author), Venetia A. Whiteside (22436866) (author), Divya Pillutla (22436869) (author), Shrey Ramnath (22436872) (author), Gavin P. Kinsella (22436875) (author), Piper A. Wilburn (22436878) (author), James D. Buschbach (22436881) (author), Deep A. Gandhi (22436884) (author), M. Reza Saadatzadeh (22436887) (author), L. Daniel Wurtz (22436890) (author), Patrick J. Getty (22436893) (author), Sheldon L. Padgett (22436896) (author), Rance M. Gamblin (22436899) (author), Michael O. Childress (22436902) (author), Christopher M. Fulkerson (15090300) (author), Maegan L. Capitano (22436905) (author), Karen E. Pollok (21365488) (author), Christopher D. Collier (21365482) (author), Edward M. Greenfield (22436908) (author)
Publicado: 2025
Subjects:
Cancer
Tumor Biology
Therapeutic Research and Development
Methods and Technology
Drug Discovery Technologies
Screening strategies (assays and chemical libraries)
In Vitro Models Of Cancer
Progression, Invasion & Metastasis
Tumor progression
Pediatric Cancers
Sarcomas
Osteosarcoma
Small Molecule Agents
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