The R203M and D377Y mutation of N protein promote SARS-CoV-2-VLP production in HEK293T-ACE2 cells.

(A) HEK293T cells were stably infected with Lentivirus-CT or Lentivirus-ACE2, Cell lysates were analyzed by immunoblotting. (B) Caco-2 cells were stably infected with Lentivirus-CT or Lentivirus-N, Cell lysates were analyzed by immunoblotting. ...

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المؤلف الرئيسي:	Yongkui Li (5642561) (author)
مؤلفون آخرون:	Moran Li (1837711) (author), Heng Xiao (489521) (author), Feng Liao (458424) (author), Miaomiao Shen (7916312) (author), Weiwei Ge (7257905) (author), Junxian Ou (10801050) (author), Yuqing Liu (103879) (author), Lumiao Chen (20598543) (author), Yue Zhao (186573) (author), Pin Wan (3622859) (author), Jinbiao Liu (576171) (author), Jun Chen (4238) (author), Xianwu Lan (20598546) (author), Shaorong Wu (13907973) (author), Qiang Ding (295913) (author), Geng Li (312002) (author), Qiwei Zhang (277241) (author), Pan Pan (636461) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Microbiology Molecular Biology Evolutionary Biology Immunology Cancer Mental Health Infectious Diseases Virology Biological Sciences not elsewhere classified mediated interferon induction mediated antiviral signaling intracellular signal regulation ifn -&# 946 viral genome assembly 2 &# 8201 viral rna compared 2 infection therein viral protein mutations n protein mutations viral rna viral evolution n protein two mutations 2 participates 2 infectivity xlink "> well understood virus evolution thus alter suppressive activity study helps studies indicate site 377 site 203 modify virus irf3 phosphorylation inhibitory impact immune interference host interactions effectively attenuating biological function binding activity
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The R203M and D377Y mutation of N protein promote SARS-CoV-2-VLP production in HEK293T-ACE2 cells.

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