Analysis of HK2-<i>SOX10</i> mRNA interaction.

Analysis of HK2-<i>SOX10</i> mRNA interaction.

<p><b>(A)</b> western blot of HK2 and GAPDH (normalization control) from RIP experiment performed on A375 and <b>(B)</b> A2058 melanoma cell lines (representative images, <i>n</i> = 3 biological replicates). <b>(C)</b> <i>In silico</i>...

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Main Author:	Ana Luisa Dian (22258504) (author)
Other Authors:	Lucilla Fabbri (5040347) (author), Antoine Moya-Plana (18204611) (author), Giuseppina Claps (367291) (author), Juliana C. Ferreira (22258507) (author), Céline M. Labbé (5204630) (author), Virginie Quidville (14913732) (author), Sylvain Martineau (22706) (author), Dorothée Baille (22258510) (author), Laetitia Besse (19249177) (author), Cédric Messaoudi (22258513) (author), Séverine Roy (14927597) (author), Virginie Raynal (29237) (author), Sylvain Baulande (5113562) (author), Wael M. Rabeh (1850482) (author), Caroline Robert (103600) (author), Stéphan Vagner (2936631) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Genetics Molecular Biology Pharmacology Cancer Virology Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified transcription factor implicated outer mitochondrial membrane including crosslinking immunoprecipitation highly promising area clearly established yet 5 ′ utr metabolic functions linked although metabolic benefits key glycolytic enzymes high glucose conditions clip ), indicate protein interaction assays rna sequencing indicate regulates mrna translation regulate mrna translation pyruvate kinase 2 melanoma cell lines hk2 directly interacts div >< p mrna encoding sox10 rbp whose interaction translational regulation exerted melanoma cell proliferation cell proliferation mrna translation mrna interaction glucose kinase metabolic status translational control sox10 </ hexokinase 2 glycolytic pathway binding protein hk2 ), bind glucose using rna tumor initiation tumor growth tumor cells phosphate dehydrogenase nonmetabolic function hk2 acting hk2 -< gene expression first step extensively described enzymatic activity energetic pathway data highlight critical effector
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