Alterations in N. fowleri mitotic α tubulins matching the tubulin mutations database entries for drug resistance or sensitization.

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Jacopo Zattoni (21702634) (author)
مؤلفون آخرون:	Richard F. Ludueña (21702637) (author), Maral Aminpour (3596306) (author), Jack A. Tuszynski (160860) (author)
منشور في:	2025
الموضوعات:	Microbiology Neuroscience Pharmacology Evolutionary Biology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified promising approach given potential therapeutic agents pathogen however remains necrotizing inflammation called employed bioinformatics tools designing novel derivatives colchicine analogs retain 97 %, due eating amoeba (< colchicine binding site naegleria fowleri </ mitotic tubulins show animal pathogen well fowleri </ amoeba ’ vivo .</ unclear view therefore believe targeting therapies suitable target starting point significant number selected ligands safer profile rational derivatization pathogenic factors mortality rate host ’ established microtubule effective treatment drugs resistance digest neurons consensus method computational discovery clinical practices ccsb ’ binding affinity autodock vina although infections acid sequences
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Alterations in <i>N. fowleri</i> mitotic α tubulins matching the tubulin mutations database entries for drug resistance or sensitization.