Flow cytometry and immunohistochemistry analysis confirm an increased presence of CD206+Trem2+ macrophages in MRL knee joints.

A) Proportion of Mrc1+ and Mrc1+Trem2+ Mono/Macs relative to total immune cells sequenced in both B6 (solid...

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Bibliographic Details
Main Author:	Jillian L. McCool (13174542) (author)
Other Authors:	Aimy Sebastian (823355) (author), Nicholas R. Hum (12563075) (author), Stephen P. Wilson (13174545) (author), Oscar A. Davalos (19447159) (author), Deepa K. Murugesh (4621030) (author), Beheshta Amiri (13174548) (author), Cesar Morfin (20501089) (author), Blaine A. Christiansen (13174551) (author), Gabriela G. Loots (12563087) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Microbiology Cell Biology Physiology Pharmacology Biotechnology Evolutionary Biology Ecology Immunology Developmental Biology Hematology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified sup >+</ sup rest spontaneously resolve immune cell populations identified significant differences div >< p cell rna sequencing anterior cruciate ligament myeloid cell activation inflammatory signaling seen apoptotic cells induced murine knee joint joint injuries progress mrl injured joints potent myeloid inflammatory response induced fluctuations synovial joints traumatic osteoarthritis transcriptional shifts synovial tissue susceptible c57bl stabilizing tissues significantly contrasted resistant mrl receptor involved medial meniscus macrophage subpopulations macrophage accumulation found enriched enhanced capacity driven anti data suggest connective tissues clearing debris articular fractures
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Flow cytometry and immunohistochemistry analysis confirm an increased presence of CD206<sup>+</sup>Trem2<sup>+</sup> macrophages in MRL knee joints.