CD24-Fc treatment and HIV latency reversal delay HIV-1 rebound and reduce HIV pathogenesis after cART cessation.

<p>Humanized mice were infected with HIV, starting with cART from 6 wpi to 17wpi. CD24-Fc treatment introduced at 13 wpi until termination. Ploy(I:C) was administered at 15 wpi. All animals were terminated at 20 wpi. <b>(A)</b> Viremia detected at the indicated time points with tre...

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主要作者:	Guangming Li (607051) (author)
其他作者:	Jianping Ma (816945) (author), Haisheng Yu (607054) (author), Ourania Tsahouridis (11909960) (author), Yaoxian Lou (22022137) (author), Xiuting He (11909963) (author), Masaya Funaki (11909966) (author), Pan Zheng (25267) (author), Yang Liu (4829) (author), Lishan Su (33524) (author)
出版:	2025
主题:	Medicine Microbiology Cell Biology Neuroscience Physiology Biotechnology Immunology Cancer Mental Health Infectious Diseases Virology Chemical Sciences not elsewhere classified promising new therapeutic suboptimal immune reconstitution cd8 central memory fc may provide div >< p reduced immune hyper treating chronic inflammation pwh ), leading fc resolves inflammation associated molecular patterns 1 viral rebound systemic immune activation cart </ p chronic inflammation immune hyperactivation reduced hiv hiv cd8 chronic hiv suppressive cart retroviral therapy people infected inflammatory properties increased risk improved control humanized mice fusion protein findings indicate cell activity associated diseases aids events 1 reservoirs 1 infection
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CD24-Fc treatment and HIV latency reversal delay HIV-1 rebound and reduce HIV pathogenesis after cART cessation.

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