Structure prediction for full-length PfAspRS and PvAspRS and biochemical analysis of truncated PvAspRS.

(A) AlphaFold predicted structures of full-length PfAspRS (PlasmoDB ID: PF3D7_0102900) and full-length PvAspRS (PlasmoDB ID: PVX_081610). Model confidence is predicted and colored. Blue: Very high (pLDDT > 90), sky blue (90 > pLDDT > 70), yello...

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Detalhes bibliográficos
Autor principal:	Nutpakal Ketprasit (8466888) (author)
Outros Autores:	Chia-Wei Tai (20405150) (author), Vivek Kumar Sharma (10141326) (author), Yogavel Manickam (6754691) (author), Yogesh Khandokar (20405159) (author), Xi Ye (9547527) (author), Con Dogovski (155895) (author), David H. Hilko (19450557) (author), Craig J. Morton (1792909) (author), Anne-Sophie C. Braun (21681428) (author), Michael G. Leeming (1544020) (author), Bagale Siddharam (21681431) (author), Gerald J. Shami (13206026) (author), Pushpangadan Indira Pradeepkumar (17867002) (author), Santosh Panjikar (203871) (author), Sally-Ann Poulsen (1340772) (author), Michael D. W. Griffin (20062200) (author), Amit Sharma (46604) (author), Leann Tilley (553731) (author), Stanley C. Xie (10890198) (author)
Publicado em:	2025
Assuntos:	Biophysics Biochemistry Molecular Biology Pharmacology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified synthetic adenosine monophosphate starting point compounds highlights structural features extended region around currently deployed antimalarials ray crystallography reveals promising antimalarial target antimalarial drug target stabilized flipping loop flexible flipping loop streptomyces sp </ mechanism involves hijacking div >< p aarss ), including work reveals line antimalarial antimalarial activity vivax </ underpin differences trna synthetases trna synthetase sulfamate conjugate protein translation plasmodium </ novel mechanisms new targets natural product motif ii malaria poses increasing resistance human health falciparum </ enormous threat eif2α phosphorylation efficacy comparable current front bind substrates active site action need >- sulfamoyladenosine >- sulfamoyl 5 ′-< 5 -<
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Structure prediction for full-length <i>Pf</i>AspRS and <i>Pv</i>AspRS and biochemical analysis of truncated <i>Pv</i>AspRS.

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