Figure 1 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma

Figure 1 from Repurposing Vandetanib plus Everolimus for the Treatment of <i>ACVR1</i>-Mutant Diffuse Intrinsic Pontine Glioma

<p>Schema for AI-based identification of a repurposed drug combination strategy for <i>ACVR1</i>-mutant DIPG. The BenevolentAI knowledge graph was employed to identify approved drugs with potential potency against ACVR1 and sufficient CNS penetration to be a rational therapy for ch...

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Main Author: Diana M. Carvalho (5608127) (author)
Other Authors: Peter J. Richardson (15118576) (author), Nagore Olaciregui (15118579) (author), Reda Stankunaite (15118582) (author), Cinzia Lavarino (15107701) (author), Valeria Molinari (15110798) (author), Elizabeth A. Corley (15118585) (author), Daniel P. Smith (11197155) (author), Ruth Ruddle (15022002) (author), Adam Donovan (1385493) (author), Akos Pal (1385445) (author), Florence I. Raynaud (1269372) (author), Sara Temelso (15118588) (author), Alan Mackay (20972) (author), John P. Overington (15118591) (author), Anne Phelan (76952) (author), David Sheppard (1893940) (author), Andrew Mackinnon (194271) (author), Bassel Zebian (5986940) (author), Safa Al-Sarraj (219896) (author), Ashirwad Merve (15118594) (author), Jeremy Pryce (15118597) (author), Jacques Grill (15015216) (author), Michael Hubank (15104113) (author), Ofelia Cruz (9950930) (author), Andres Morales La Madrid (343870) (author), Sabine Mueller (5350358) (author), Angel M. Carcaboso (15053699) (author), Fernando Carceller (14945229) (author), Chris Jones (25458) (author)
Published: 2025
Subjects:
Cancer
Therapeutic Research and Development
Clinical Research and Trials
Methods and Technology
Clinical-Stage Research
CNS Cancers
Gliomas, Glioblastomas
Computational Methods
Algorithms
Drug Discovery Technologies
Drug Targets
Pediatric Cancers
Pharmacology
Pharmacokinetics and pharmacodynamics
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