A Novel Strategy to Rapidly Profile and Quantify High-Risk Host Cell Proteins Using Integrated DDA-PRM-dMRM Mode

Host cell proteins (HCPs) are critical process-related impurities in biotherapeutics that threaten drug stability and safety. The substantial dynamic range (>5 orders of magnitude) between therapeutic proteins and residual HCPs often leads to difficulty in detecting high-risk species. Herein, we...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας:	Xuan Xu (781842) (author)
Άλλοι συγγραφείς:	Lan Wang (85307) (author), Gang Wu (23885) (author), Shengyuan Xu (543269) (author), Yang Li (7082) (author), Ning Sheng (692423) (author), Jinlan Zhang (600633) (author)
Έκδοση:	2025
Θέματα:	Biophysics Medicine Immunology Developmental Biology Cancer Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Information Systems not elsewhere classified threaten drug stability multiple reaction monitoring downstream purification processes chinese hamster ovary cell spectral library 38 reported high potential hcps present new dynamic mrm cho cell samples accurately quantify high 28 known high quantify high 28 high existing high detecting high unknown hcps unique peptides therapeutic proteins risk species risk hcps related impurities rapidly profile rapid quantification dependent acquisition critical process constructed library comprehensively profile comprehensive profiling 47 peptides
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A Novel Strategy to Rapidly Profile and Quantify High-Risk Host Cell Proteins Using Integrated DDA-PRM-dMRM Mode

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