PI3K-Seeker: A Machine Learning-Powered Web Tool to Discover PI3K Inhibitors

Phosphatidylinositol 3-kinases (PI3Ks) play a crucial role in human metabolism, and their dysregulation contributes to the development of several metabolic disorders, including cancer. Despite advances in experimental high-throughput screening, discovering new therapeutic agents remains challenging...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Francisca Joseli Freitas de Sousa (22640155) (author)
مؤلفون آخرون:	Dinler Amaral Antunes (7343948) (author), Geancarlo Zanatta (1735618) (author)
منشور في:	2025
الموضوعات:	Biochemistry Genetics Cancer Biological Sciences not elsewhere classified Information Systems not elsewhere classified web server based several metabolic disorders pubchem fingerprints extracted powered web tool http :// www stage prediction process second stage first stage xgboost algorithm trained using throughput screening second refines potent inhibitors machine learning large set including cancer human metabolism high probability experimental high dysregulation contributes distinct datasets despite advances data enhancement crucial role 994 ).
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PI3K-Seeker: A Machine Learning-Powered Web Tool to Discover PI3K Inhibitors

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