Image 3_Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.tif
Background<p>The relationship between systemic immune-inflammation biomarkers, the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI), and cardiovascular disease (CVD) in cardiovascular-kidney-metabolic (CKM) syndrome remains unclear.</p>Methods&...
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| _version_ | 1849927644592734208 |
|---|---|
| author | Chen Pengfei (22675154) |
| author2 | Megan Lui (22675157) Lixiao Zhang (529808) Chen Chen (6544) Tianyu Wang (397547) Hou Ailin (22675160) Deng Pan (47215) Wenxi Yu (4373743) Jianpeng Du (11388092) Ming Guo (34061) Dazhuo Shi (3586349) |
| author2_role | author author author author author author author author author author |
| author_facet | Chen Pengfei (22675154) Megan Lui (22675157) Lixiao Zhang (529808) Chen Chen (6544) Tianyu Wang (397547) Hou Ailin (22675160) Deng Pan (47215) Wenxi Yu (4373743) Jianpeng Du (11388092) Ming Guo (34061) Dazhuo Shi (3586349) |
| author_role | author |
| dc.creator.none.fl_str_mv | Chen Pengfei (22675154) Megan Lui (22675157) Lixiao Zhang (529808) Chen Chen (6544) Tianyu Wang (397547) Hou Ailin (22675160) Deng Pan (47215) Wenxi Yu (4373743) Jianpeng Du (11388092) Ming Guo (34061) Dazhuo Shi (3586349) |
| dc.date.none.fl_str_mv | 2025-11-24T14:43:31Z |
| dc.identifier.none.fl_str_mv | 10.3389/fnut.2025.1661826.s003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Image_3_Association_of_SII_and_SIRI_with_incidence_of_cardiovascular_disease_in_cardiovascular-kidney-metabolic_syndrome_a_prospective_cohort_study_tif/30695384 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical and Sports Nutrition cardiovascular disease incidence cardiovascular-kidney-metabolic syndrome systemic immune-inflammation index systemic inflammation response index UK biobank |
| dc.title.none.fl_str_mv | Image 3_Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.tif |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | Background<p>The relationship between systemic immune-inflammation biomarkers, the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI), and cardiovascular disease (CVD) in cardiovascular-kidney-metabolic (CKM) syndrome remains unclear.</p>Methods<p>Individuals with CKM syndrome at stages 0–3 from UK Biobank were included in this study. Cox regression models were used to assess the association of SII and SIRI with incidence of CVD. Restricted cubic spline (RCS) models were applied to examine nonlinear longitudinal associations. Subgroup stratified by CKM stages were analyzed.</p>Results<p>A total of 301,631 participants with CKM stages 0 (14.1%), 1 (19.4%), 2 (56.7%), and 3 (9.8%) were included in this study. During a median follow-up of 13.0 years, CVD incidence occurred in 35,782 (11.86%) participants. After adjustment, the elevated SII (HR: 1.07, 95% CI: 1.05–1.10, p < 0.001) and SIRI (HR: 1.31, 95% CI: 1.26–1.37, p < 0.001) were associated with the risk of CVD incidence. RCS analyses indicated a U-shaped association for SII and a monotonic increase for SIRI. Subgroup analyses revealed significantly stronger associations between both SII and SIRI and the incidence of CVD with CKM stages.</p>Conclusion<p>As the main systemic immune-inflammation biomarkers, the elevated SII and SIRI in CKM syndrome were significantly associated with increased risk of CVD incidence.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_ef7ba9c2c328c5c63194d6a8feebbe06 |
| identifier_str_mv | 10.3389/fnut.2025.1661826.s003 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30695384 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Image 3_Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.tifChen Pengfei (22675154)Megan Lui (22675157)Lixiao Zhang (529808)Chen Chen (6544)Tianyu Wang (397547)Hou Ailin (22675160)Deng Pan (47215)Wenxi Yu (4373743)Jianpeng Du (11388092)Ming Guo (34061)Dazhuo Shi (3586349)Clinical and Sports Nutritioncardiovascular disease incidencecardiovascular-kidney-metabolic syndromesystemic immune-inflammation indexsystemic inflammation response indexUK biobankBackground<p>The relationship between systemic immune-inflammation biomarkers, the Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI), and cardiovascular disease (CVD) in cardiovascular-kidney-metabolic (CKM) syndrome remains unclear.</p>Methods<p>Individuals with CKM syndrome at stages 0–3 from UK Biobank were included in this study. Cox regression models were used to assess the association of SII and SIRI with incidence of CVD. Restricted cubic spline (RCS) models were applied to examine nonlinear longitudinal associations. Subgroup stratified by CKM stages were analyzed.</p>Results<p>A total of 301,631 participants with CKM stages 0 (14.1%), 1 (19.4%), 2 (56.7%), and 3 (9.8%) were included in this study. During a median follow-up of 13.0 years, CVD incidence occurred in 35,782 (11.86%) participants. After adjustment, the elevated SII (HR: 1.07, 95% CI: 1.05–1.10, p < 0.001) and SIRI (HR: 1.31, 95% CI: 1.26–1.37, p < 0.001) were associated with the risk of CVD incidence. RCS analyses indicated a U-shaped association for SII and a monotonic increase for SIRI. Subgroup analyses revealed significantly stronger associations between both SII and SIRI and the incidence of CVD with CKM stages.</p>Conclusion<p>As the main systemic immune-inflammation biomarkers, the elevated SII and SIRI in CKM syndrome were significantly associated with increased risk of CVD incidence.</p>2025-11-24T14:43:31ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.3389/fnut.2025.1661826.s003https://figshare.com/articles/figure/Image_3_Association_of_SII_and_SIRI_with_incidence_of_cardiovascular_disease_in_cardiovascular-kidney-metabolic_syndrome_a_prospective_cohort_study_tif/30695384CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306953842025-11-24T14:43:31Z |
| spellingShingle | Image 3_Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.tif Chen Pengfei (22675154) Clinical and Sports Nutrition cardiovascular disease incidence cardiovascular-kidney-metabolic syndrome systemic immune-inflammation index systemic inflammation response index UK biobank |
| status_str | publishedVersion |
| title | Image 3_Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.tif |
| title_full | Image 3_Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.tif |
| title_fullStr | Image 3_Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.tif |
| title_full_unstemmed | Image 3_Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.tif |
| title_short | Image 3_Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.tif |
| title_sort | Image 3_Association of SII and SIRI with incidence of cardiovascular disease in cardiovascular-kidney-metabolic syndrome: a prospective cohort study.tif |
| topic | Clinical and Sports Nutrition cardiovascular disease incidence cardiovascular-kidney-metabolic syndrome systemic immune-inflammation index systemic inflammation response index UK biobank |