AdipoRon increases AdipoR-dependent AM fungal killing and reverses inflammatory phenotype.

Wild-type or APN pathway-deficient AMs were infected and treated with AdipoRon or vehicle to determine the effect of AdipoRon on fungal killing, cytokine transcription and secretion as described in Materials and Methods. A. Timeline for ex vivo cultured...

وصف كامل

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Sri Harshini Goli (20889928) (author)
مؤلفون آخرون:	Joo-Yeon Lim (11556997) (author), Nese Basaran-Akgul (20889931) (author), Steven P. Templeton (6688916) (author)
منشور في:	2025
الموضوعات:	Biochemistry Microbiology Ecology Immunology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified antifungal host defense although innate immunity adipokine produced mainly observed increased mortality increased fungal burden enhanced fungal killing decreased fungal killing deficient ams exhibited div >< p canonical lc3 pathway aspergillus fumigatus </ apn -/- ams apn receptors adipor1 fumigatus </ mediated killing increased activation lack apn study identifies pharmacological stimulation novel role neutropenic mice invasive aspergillosis inflammatory phenotype inflammatory effects exerts anti either receptor distal tissues alveolar macrophages
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

AdipoRon increases AdipoR-dependent AM fungal killing and reverses inflammatory phenotype.

مواد مشابهة