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<div><p>Drug-resistant tuberculosis is a pressing global health issue that requires the development of new drugs or the identification of new therapeutic targets. The ESX-3 secretion system is essential for the <i>Mycobacterium tuberculosis</i> growth and plays a role in iron...

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Main Author:	Ana Laura Granados-Tristán (21144439) (author)
Other Authors:	Mauricio Carrillo-Tripp (3183507) (author), Carlos Eduardo Hernández-Luna (21144442) (author), Aldo Herrera-Rodulfo (21144445) (author), Laura Adiene González-Escalante (8890166) (author), Ana Leticia Arriaga-Guerrero (8890154) (author), Beatriz Silva-Ramírez (8890169) (author), Brenda Leticia Escobedo-Guajardo (18809428) (author), Roberto Mercado-Hernández (8890172) (author), Mario Bermúdez de León (21144448) (author), Katia Peñuelas-Urquides (11639896) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Medicine Microbiology Molecular Biology Pharmacology Biotechnology Cancer Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified inhibited using crispri 3 secretion system favorable δg values tertiary protein structures new therapeutic targets eccd3 dimer interfaces div >< p mycolicibacterium smegmatis </ mycobacterium tuberculosis </ ivermectin susceptibility increased mycobacterium susceptibility smegmatis </ tuberculosis </ new drugs molecular structures ivermectin targets eccd3 protein eccd3 increased best δg resistant tuberculosis vitro </ silico </ eccd3 </ zinc homeostasis quaternary interface prospective drugs predicted based preclinical studies ivermectin action compensatory mechanisms
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Ligands includes in this study.

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