RSK inhibitors suppress ORF45-induced Filamin A phosphorylation.
<p>The solvent DMSO, 10 μM BI-D1870 or 10 μM SL0101 was added to ORF45-overexpressing HEK293 cells (A), iSLK.Bac16 cells undergoing Dox + NaB-induced lytic reactivation (B) and HEK293 cells infected with Bac16 virions (MOI = 10) (C) for 24 h, the cells were collected and the whole cell extract...
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2025
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| _version_ | 1849927641672450048 |
|---|---|
| author | Xiaojuan Li (351842) |
| author2 | Li Quan (177024) Rihong Zhou (22676690) Xiangpeng Liu (17898881) Ronit Sarid (186795) Ersheng Kuang (129028) |
| author2_role | author author author author author |
| author_facet | Xiaojuan Li (351842) Li Quan (177024) Rihong Zhou (22676690) Xiangpeng Liu (17898881) Ronit Sarid (186795) Ersheng Kuang (129028) |
| author_role | author |
| dc.creator.none.fl_str_mv | Xiaojuan Li (351842) Li Quan (177024) Rihong Zhou (22676690) Xiangpeng Liu (17898881) Ronit Sarid (186795) Ersheng Kuang (129028) |
| dc.date.none.fl_str_mv | 2025-11-24T18:34:13Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.ppat.1013737.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/RSK_inhibitors_suppress_ORF45-induced_Filamin_A_phosphorylation_/30697673 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Microbiology Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Virology s2152a knockin abolish primary effusion lymphoma multicentric castleman disease kaposi &# 8217 mediated viral infection infected adherent cells differentiated b cells sequential cell detachment mediated kshv transmission kshv lytic replication adherent cells lytic replication viral transmission kshv transmission cell detachment b lymphocytes lytic cycle cell transmission taken together results demonstrated radically support natural donors key role key regulator etiological agent dependent manner cell contact cell adhesion associated herpesvirus |
| dc.title.none.fl_str_mv | RSK inhibitors suppress ORF45-induced Filamin A phosphorylation. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>The solvent DMSO, 10 μM BI-D1870 or 10 μM SL0101 was added to ORF45-overexpressing HEK293 cells (A), iSLK.Bac16 cells undergoing Dox + NaB-induced lytic reactivation (B) and HEK293 cells infected with Bac16 virions (MOI = 10) (C) for 24 h, the cells were collected and the whole cell extracts were subjected to Western Blotting analysis to detect the level of Filamin A phosphorylation.</p> <p>(TIF)</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_f05392f15f49d3e980070d7661c1812c |
| identifier_str_mv | 10.1371/journal.ppat.1013737.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30697673 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | RSK inhibitors suppress ORF45-induced Filamin A phosphorylation.Xiaojuan Li (351842)Li Quan (177024)Rihong Zhou (22676690)Xiangpeng Liu (17898881)Ronit Sarid (186795)Ersheng Kuang (129028)MicrobiologyCell BiologyMolecular BiologyBiotechnologyImmunologyDevelopmental BiologyCancerInfectious DiseasesVirologys2152a knockin abolishprimary effusion lymphomamulticentric castleman diseasekaposi &# 8217mediated viral infectioninfected adherent cellsdifferentiated b cellssequential cell detachmentmediated kshv transmissionkshv lytic replicationadherent cellslytic replicationviral transmissionkshv transmissioncell detachmentb lymphocyteslytic cyclecell transmissiontaken togetherresults demonstratedradically supportnatural donorskey rolekey regulatoretiological agentdependent mannercell contactcell adhesionassociated herpesvirus<p>The solvent DMSO, 10 μM BI-D1870 or 10 μM SL0101 was added to ORF45-overexpressing HEK293 cells (A), iSLK.Bac16 cells undergoing Dox + NaB-induced lytic reactivation (B) and HEK293 cells infected with Bac16 virions (MOI = 10) (C) for 24 h, the cells were collected and the whole cell extracts were subjected to Western Blotting analysis to detect the level of Filamin A phosphorylation.</p> <p>(TIF)</p>2025-11-24T18:34:13ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.ppat.1013737.s001https://figshare.com/articles/figure/RSK_inhibitors_suppress_ORF45-induced_Filamin_A_phosphorylation_/30697673CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306976732025-11-24T18:34:13Z |
| spellingShingle | RSK inhibitors suppress ORF45-induced Filamin A phosphorylation. Xiaojuan Li (351842) Microbiology Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Virology s2152a knockin abolish primary effusion lymphoma multicentric castleman disease kaposi &# 8217 mediated viral infection infected adherent cells differentiated b cells sequential cell detachment mediated kshv transmission kshv lytic replication adherent cells lytic replication viral transmission kshv transmission cell detachment b lymphocytes lytic cycle cell transmission taken together results demonstrated radically support natural donors key role key regulator etiological agent dependent manner cell contact cell adhesion associated herpesvirus |
| status_str | publishedVersion |
| title | RSK inhibitors suppress ORF45-induced Filamin A phosphorylation. |
| title_full | RSK inhibitors suppress ORF45-induced Filamin A phosphorylation. |
| title_fullStr | RSK inhibitors suppress ORF45-induced Filamin A phosphorylation. |
| title_full_unstemmed | RSK inhibitors suppress ORF45-induced Filamin A phosphorylation. |
| title_short | RSK inhibitors suppress ORF45-induced Filamin A phosphorylation. |
| title_sort | RSK inhibitors suppress ORF45-induced Filamin A phosphorylation. |
| topic | Microbiology Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Infectious Diseases Virology s2152a knockin abolish primary effusion lymphoma multicentric castleman disease kaposi &# 8217 mediated viral infection infected adherent cells differentiated b cells sequential cell detachment mediated kshv transmission kshv lytic replication adherent cells lytic replication viral transmission kshv transmission cell detachment b lymphocytes lytic cycle cell transmission taken together results demonstrated radically support natural donors key role key regulator etiological agent dependent manner cell contact cell adhesion associated herpesvirus |