Distinguishing <i>N</i>‑Terminal Methylation from Near-Isobaric Modifications by Statistical Analysis of Mass Error Distributions of Fragment Ions

α-<i>N</i>-Terminal methylation is an understudied post-translational modification involved in protein–protein or protein–DNA interactions. Its global profiling by mass spectrometry is challenging due to low abundance and interference from near-isobaric modifications like Nt-acetylation,...

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Glavni avtor:	Hankyul Lee (3127563) (author)
Drugi avtorji:	Shinyeong Ju (4854385) (author), Seonjeong Lee (7365998) (author), So Ha Lee (21837558) (author), Sang-Yoon Kim (627416) (author), Narae Park (4635103) (author), Cheol-Sang Hwang (344390) (author), Kang-Sik Park (760824) (author), Cheolju Lee (491843) (author)
Izdano:	2025
Teme:	Biophysics Biochemistry Genetics Molecular Biology Sociology Inorganic Chemistry Infectious Diseases Chemical Sciences not elsewhere classified protein – protein predicted retention times mass error test mass error distributions >‑ terminal methylation >- terminome enrichment translational modification involved >- terminal methylation -, b -, falsely assigned nt >- terminome falsely assigned mass spectrometry ∼ 17 useful tool understudied post trimethyl psms statistical analysis results indicate repurposed dataset reassign nt potentially nt net change n </ ms2 spectra modified psms methylated spectra methylated proteins manual inspection low abundance isobaric nt isobaric modifications ion proportions global profiling complex proteomes challenging due
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Distinguishing <i>N</i>‑Terminal Methylation from Near-Isobaric Modifications by Statistical Analysis of Mass Error Distributions of Fragment Ions

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