HU-induced ER expansion is reversible and mimicked by thiol stress.

<p><b>(A)</b> Confocal microscopy images comparing a nucleus with even NPC and ER distributions, as tagged by Cut11-GFP and mCherry-AHDL respectively (left), and a nucleus with an N-Cap after incubating 3 hours in 75 mM HU (right). ‘a’ marks the last time point before N-Cap redistr...

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Bibliographic Details
Main Author:	Ana Sánchez-Molina (22648139) (author)
Other Authors:	Manuel Bernal (179798) (author), Joel D. Posligua-García (22648142) (author), Antonio J. Pérez-Pulido (9754780) (author), Laura de Cubas (13037335) (author), Elena Hidalgo (51458) (author), M.-Henar Valdivieso (142037) (author), Silvia Salas-Pino (179803) (author), Rafael R. Daga (22648148) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Molecular Biology Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified Information Systems not elsewhere classified schizosaccharomyces pombe </ proper redox environment protein folding within dependent protein folding nuclear pore complexes disulfide bond formation dia treatments resulted triggers er expansion oxidative stress response er expansion results hu impacts redox div >< p antineoplastic agent hydroxyurea disulfide stress correct folding reducing agent nuclear envelope dia ), thiol stress striking phenotype ssa1 chaperones specific region specific inducer secretory pathway rapidly reversed proteins entering precise mechanisms misfolded proteins lumen provides hydroxyurea induces fully elucidated forming membranes endoplasmic reticulum data show
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HU-induced ER expansion is reversible and mimicked by thiol stress.

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